As we know that asbestos can break up into tiny fibers when they are damaged and those tiny fibers may be inhaled by human and stay in the lung to cause numerous health problems. To analyze the asbestos abnormalities in human bodies, high resolution CT scans should be used frequently. Taken by – American Journal of Roentgenology, Vol 151, Issue 5, 883-891, there is an interesting study concerned about this subject entitled, High resolution CT of benign asbestos-related diseases: clinical and radiographic correlation” by DR Aberle, G Gamsu, and CS Ray – Department of Radiological Sciences, University of California Los Angeles School of Medicine 90024. This writing is about:
An analysis about benign asbestos related pleural and parenchymal abnormalities of 100 workers who expose to asbestos in their work has been done by using high-resolution CT scans and diagnose them clinically. In the evaluation, all subjects had high resolution CT scans which is connected to conventional CT scans. High-resolution of CT scans are set as high, intermediate or low in order to evaluate for asbestosis. Different probability of basic asbestosis in multiplicity and extended observation can affect the change parenchymally. In linear regression analysis, parenchymal bands are included in the most distinctive high-resolution CT features of asbestosis along with thickened nondependent interstitial short lines. Based on the observation about 45 subjects satisfying clinical criteria of asbestosis, the probability of high-resolution CT of asbestosis was 38 (84%) for the high one, intermediate in five (11%), and low in two (4%). There are 55 subjects with 20 of them don’t have clinical asbestosis. A high probability in parenchymal abnormalities indicative was observed on high-resolution CT. A strong positive correlation between high-resolution CT and chest radiographic profusion scores for less than 0.0001, while with asbestos-related pleural thickening, it still scores less than 0.0001. In the correlation with forced vital capacity, it shows less than 0.006 and single-breath diffusing capacity scores less than 0.03 for both functional measures of restrictive interstitial lung disease. Clubbing and rales don’t have prevalence sufficiently in having statictical correlation with high-resolution CT scores. It is very sensitive to have high-resolution CT in detecting both pleural and parenchymal abnormalities in the asbestos-exposed subject. The observation od asbestos-related pleural changes are done more frequently on high-resolution CT than on conventional one or even chest radiography.
Another study about it entitled “Asbestos exposure and the risk of lung cancer in a general urban population.” By Karjalainen A, Anttila S, Vanhala E, and Vainio H – Finnish Institute of Occupational Health, Helsinki – Scand J Work Environ Health. 1994 Aug;20(4):243-50 contained that the purposes of the study is investigating lung cancer caused by asbestos based on the histological type of cancer, lobe of origin, pulmonary concentration, and type of amphibole fibers and the estimation of the etiologic fraction of asbestos for lung cancer. The methods of scanning electron microscopy is used to determine the pulmonary concentration of asbestos fibers in 113 surgically treated male lung cancer patients and 297 autopsy cases among men. Based on the pulmonary fiber concentration for all lung cancer types, squamous-cell carcinoma, and adenocarcinoma and for the lower-lobe and the upper- and middle-lobe cancers, the calculation of the age- and smoking-adjusted odds ratios of lung cancer is done.
The result of the observation is that lung cancer risk is increased based on the pulmonary concentration of asbestos fibers (f) of 1.0 to 4.99 x 10(6) f.g-1 [odds ratio (OR) 1.7] and > or = 5.0 x 10(6) f.g-1 (OR 5.3). The association od odds ratio with fiber concentrations of > or = 1.0 x 10(6) f.g-1 were higher for adenocarcinoma (OR 4.0) than for squamous-cell carcinoma (OR 1.6). The risk of asbestos-associated for lower lobe tumors was hinger than upper lobe tumors. The estimation of the rosk for anthophyllite and crocidolite-amosite fibers were similar, but not for the risk of squamous-cell carcinoma. In the greater Helsinki area, an etiologic fraction for asbestos among male surgical lung cancer patients is around 19%. The conclusion is in southern Finland, past exposure to asbestos is an essential factor for etiology of lung cancer. Pulmonary adenocarcinoma and lower-lobe tumors has a higher risk of asbestos-associated than squamous-cell carcinoma and upper-lobe tumors.
If you think that these studies are helpful, reading them in the entirety will do good for you. This article should not be used as a medical advice.